Dental and Periodontal Health in Obese Adolescents: Clinical, Biochemical, and Microbiological Evaluation (PERIOBESITY)

Marmara University

Status: Completed

Conditions: Dental Caries; Dental Plaque; Inflammation Biomarkers; Pediatric Obesity; Periodontal Disease

Study type: Observational

Funder types: Other

Identifiers

NCT07086027

Ethics Committee (Other Identifier)

2017-107

Details and patient eligibility

About

This study aims to investigate whether obesity affects oral and gum health in children and adolescents. A total of 75 children aged 8 to 13 years participated, including both obese and non-obese individuals. All participants received a dental examination, and samples of saliva, blood, and gum fluid were collected to measure specific inflammation-related substances (such as IL-1α, IL-1β, and leptin). The presence of specific bacteria in the mouth was also analyzed.

Full description

This cross-sectional observational study aimed to investigate the relationship between pediatric obesity and periodontal health by integrating clinical, biochemical, and microbiological assessments. A total of 75 adolescents (36 obese and 39 non-obese), aged 8-13 years, were enrolled. Clinical oral evaluations included dft, DMFT, plaque index (PI), gingival index (GI), and probing depth (PD). Blood, saliva, and gingival crevicular fluid (GCF) samples were collected for ELISA-based measurement of pro-inflammatory biomarkers (IL-1α, IL-1β, and leptin). Subgingival plaque samples were analyzed using real-time PCR to quantify six key periodontal pathogens.

Enrollment: 75 patients

Sex: All

Ages: 8 to 13 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Children aged between 8 and 13 years

Parental consent obtained

No systemic diseases other than obesity

No current medication use

Exclusion criteria

Use of antibiotics or anti-inflammatory drugs in the past 3 months

History of systemic disease (other than obesity for the obese group)

Undergoing orthodontic treatment

Missing permanent first molars

Uncooperative behavior during examination

Trial design

75 participants in 2 patient groups

Obese Group

Description:

Adolescents aged 8-13 years with a body mass index (BMI) above the 95th percentile for age and sex, classified as obese. Participants underwent dental examination and provided saliva, serum, gingival crevicular fluid (GCF), and subgingival plaque samples for biomarker and microbiological analysis.

Control Group (Normal Weight)

Description:

Adolescents aged 8-13 years with a BMI between the 5th and 85th percentiles for age and sex, considered to have normal weight. The same clinical and sample collection procedures were applied as in the obese group.