Dental Hygiene and Peri-Implant Tissues Homeostasis Ancillary Study

University of Washington

Status: Completed

Conditions: Peri-Implantitis

Treatments: Procedure: Peri-implantitis debridement; Other: Dental hygiene procedures

Study type: Interventional

Funder types: Other

Identifiers

NCT03917264

STUDY00002852A

Details and patient eligibility

About

Peri-implantitis is an inflammatory disease that leads to loss of jawbone around dental implants. Recent discoveries have identified increased release of Titanium (Ti) particles around implants as being associated to peri-implantitis. In this ancillary study to the Dental Hygiene and Peri-Implant Tissues Homeostasis trial the objective is to determine potential triggers of increased Ti dissolution from the implant surface and the mechanisms by which Ti dissolution products amplify peri-implant inflammation. Results from this study will determine whether there is a differential response to Ti particles across individuals, which may alter susceptibility to peri-implantitis.

Enrollment: 34 patients

Sex: All

Ages: 25+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Is the subject ≥ 25 years of age?
• Does the subject have an implant with a probing depth ≥ 5mm, bleeding on probing, and radiographic bone loss of > 2mm?
• Is the subject committed to the study and the required follow-up visits?

Exclusion criteria

• Is the subject immune compromised? Is the subject diabetic? Does the subject take steroid medication? Does the subject regularly use non-steroidal anti-inflammatories? Is the subject pregnant or intending to become pregnant during the duration of the study? Has the subject had previous implantoplasty? Did the subject take any antibiotics in the last 3 months?

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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34 participants in 2 patient groups

Tooth-borne treatment

Active Comparator group

Description:

Titanium curettes

Treatment:

Other: Dental hygiene procedures

Procedure: Peri-implantitis debridement

Implant-specific treatment

Experimental group

Description:

Implant brush

Treatment:

Other: Dental hygiene procedures

Procedure: Peri-implantitis debridement