Depression and Driving (D&D)

Ganesh Babulal

Status: Enrolling

Conditions: Drive; Depression

Treatments: Drug: [11C]-Pittsburgh Compound B ([11C]PiB); Drug: F 18 AV-1451 (Flortaucipir)

Study type: Observational

Funder types: Other

Identifiers

NCT05446805

202003209

Details and patient eligibility

About

This project will assess how depression, preclinical AD, and antidepressants affect driving behavior in cognitively normal older adults (65 years).

Full description

The long-term goal is to accurately identify who is at risk of decline in driving, to forecast when decline will occur, and to intervene before decline, thereby reducing the numbers of crashes, injuries, and death in older adults. The findings indicate that the long preclinical stage of Alzheimer disease (AD), as reflected in amyloid imaging and cerebrospinal fluid (CSF) biomarkers among cognitively normal participants, is associated with poorer driving performance on a standardized road test. This project will assess how depression, preclinical AD, and antidepressants affect driving behavior in cognitively normal older adults (65 years).

Enrollment: 150 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Drive on average at least once per week
• Has a valid driver's license
• Willing to complete blood draw
• Willing to complete either lumbar puncture or PET imaging
• 65 years or older
• Speaks English

Exclusion criteria

• Not willing to complete blood draw and/or one other biomarker
• Less than 65 years of age
• Does not drive a vehicle/ is no longer actively driving

Trial design

150 participants in 2 patient groups

depression

Description:

All participants will receive two one time PET scans with tracers AV1451 and PIB to detect tau and amyloid in the brain.

Treatment:

Drug: [11C]-Pittsburgh Compound B ([11C]PiB)

Drug: F 18 AV-1451 (Flortaucipir)

control

Description:

All participants will receive two one time PET scans with tracers AV1451 and PIB to detect tau and amyloid in the brain.

Treatment:

Drug: [11C]-Pittsburgh Compound B ([11C]PiB)

Drug: F 18 AV-1451 (Flortaucipir)