Depression and Facial Identity Recognition Abilities in Patients With Multiple Sclerosis (SepDep)

Lille Catholic University

Status

Unknown

Conditions

Multiple Sclerosis

Depression

Treatments

Other: Neuropsychological and emotional evaluation with monitoring

Study type

Observational

Funder types

Other

Identifiers

NCT02468765

RC-P0040

Details and patient eligibility

About

Cognitive and emotional disorders are often encountered in multiple sclerosis (MS) cases: depressive and bipolar disorders are twice as frequent as in general population.

Cognitive disorders, (particularly attention and dysexecutive disorders), appear in early stages of the disease's evolution, in cases of lightly or moderately disabled patients, with a recent evolution, with a "minor" form of the disease, even in Clinically Isolated Syndromes (CIS). Emotional disturbances are essentially linked to mood disorders of depression-type.

Last ten years, emotional processing in multiple sclerosis cases was investigated in various trials, especially regarding the recognition of facial and emotional expressions. These studies reported data, supporting an impairment of the perception of emotion, particularly those with negative valence.

The objective of this study is to investigate the link between recognition of facial and emotional expressions and depression in multiple sclerosis cases.

Enrollment

90 estimated patients

Sex

All

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Man or Woman between 18 and 65 years old
Participant understanding and able to speak French
Participant understanding the Participant Informed Sheet and who has signed the Informed Consent
Participant with Health Insurance

MS Patients :

Patient with relapsing remitting multiple sclerosis form
Expanded Disability Status Scale (EDSS) < 4
Patient without motor disorders, cerebellar or significant upper limb somatosensory or visual disturbances

Control Participants :

Participant without global cognitive deterioration

Exclusion criteria

Participant taking part of other biomedical studies involving drug tests
Participant with other neurological pathologies, head trauma with loss of consciousness, psychiatric pathologies, serious general affections, alcoholism, perception disorders, dysarthria, disorders preventing oral communication and reading, under prescription of psychotropic drugs
Mental or visual incapacity to take part in the study
Participant with antecedents of drug or alcohol abuse
Allergy to the components of the gel used during the EEG
Patients with MRI contraindications : Pacemaker or neurostimulator or Implantable Cardioverter Defibrillator (ICD), Cochlear Implants, ocular or cerebral ferromagnetic foreign body close to the nerve structures, metal prostheses,
Uncooperative or agitated patients,
Claustrophobic patients,
Ventricular peritoneal shunts and neurosurgical valves,
Braces
MS patient without MRI in the last 4 months
Adults under guardianship, under judicial protection, persons deprived of liberty,
Pregnant or breast feeding women,
MS patient with another MS form than Relapsing-Remitting,
MS patient who encountered a relapse in the last 6 weeks,
MS patient treated with corticoids in the last month.