Depression in the Elderly and Cerebral Amyloid Plaques: Characterization by [18F] AV-45 Affectives Symptoms and Amyloïd Plaques (ASAP)

Regional University Hospital Center (CHRU)

Status

Completed

Conditions

Major Depression

Elderly

Treatments

Drug: 18FAV45

Study type

Interventional

Funder types

Other

Identifiers

NCT01962753

PHRN10-VC/ ASAP

Details and patient eligibility

About

The primary objective of the study is to compare the brain amyloid load in fully, partially and non remitting depressed elderly patients at 8 weeks of antidepressant therapy, by using PET with [F18]AV45.

Full description

The main aim of this study is to assess the brain amyloid load in treated depressed elderly subjects using PET with [F18]AV45. The investigators hypothesize that the brain amyloid load will be higher in non or partially remitting depressed subjects treated with antidepressants than in fully remitting ones. An additional two years follow-up will allow comparing the brain amyloid load at baseline between those who will have evolved towards MCI or MA and those who will not, including ApoE genotype, the cognitive performances at baseline, the hippocampus volume as assessed by MRI, the type and profile of mood disorder (number of past episodes, age at first episode, vascular risk factor profile, response profile to antidepressants), as covariates.

Enrollment

92 patients

Sex

All

Ages

55+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

Adult 55 years or older
Native language : french
Study period > 7 years
Major depression defined on the DSM-IV criteria assessed by MINI and HDRS score of 10 or over
Affiliation to the national health insurance system
Signed informed consent

Exclusion Criteria

History of alcoholism or drug addiction
MMSE less than or equal to 17
Major depression with psychotic features
Depressive episode resistant, patient who received two different antidepressants well conducted without significant therapeutic response
Any current or past episode of mania, schizophrenia or any other psychotic disorder
Any past history of stroke or Parkinson's disease
Any current significant unstable illness
Any past diagnosis of Alzheimer's disease
Any current treatment by AcethylCholinesterae inhibitor, memantine or antidepressant therapy.
Contraindications to MRI in patients with:
1. Metallic foreign body eye.
2. Any implanted electronic medical irremovably (pacemaker, neurostimulator, cochlear implants ...)
3. Metal heart valve,
4. Vascular clips formerly located on cranial aneurysm.
Contraindications to antidepressants
History of progressive disease that can affect the central nervous system such as uncontrolled diabetes, blood pressure greater than or equal to 180/100; chronic lung disease with hypoxia, head trauma with loss of consciousness greater than or equal to 15 minutes; brain surgery, encephalitis, recently treated cancer (<1 year), altered cerebral metabolism including subjects with stroke sequelae extended. Patients with lacunar stroke without thalamic or striatal may be included.