Depression Screening in Patients With Lung Cancer

Memorial Sloan Kettering Cancer Center (MSK)

Status: Completed

Conditions: Lung Cancer; Depression

Treatments: Other: screening questionnaire administration; Procedure: psychosocial assessment and care; Other: study of socioeconomic and demographic variables; Other: counseling intervention

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00404365

MSKCC-06038

R01CA115349 (U.S. NIH Grant/Contract)

P30CA008748 (U.S. NIH Grant/Contract)

Mskcc 06-038

Details and patient eligibility

About

RATIONALE: Screening tests may help doctors find depression in patients with lung cancer, allow doctors to recommend treatment for depression, and improve the patient's quality of life.

PURPOSE: This randomized clinical trial is studying how well depression screening works when the results are or are not shared with patients with lung cancer and their doctor.

Full description

OBJECTIVES:

Primary

• Determine the impact of depression screening in patients with lung cancer when the results of the screening are made available to the patient, the physician, both, or neither on detection of depression, provision of depression treatment recommendations, and the quality of the doctor-patient interaction from the patient's perspective.

Secondary

• Determine psychological and demographic subsets for the impact of depression screening in these patients when the results of the screening are made available to the patient, the physician, both, or neither on the detection of depression, provision of depression treatment recommendations, and the quality of the doctor-patient interaction from the patient's perspective.

OUTLINE: This is a multicenter, randomized, double-blind, single-blind, factorial study. Patients are stratified according to participating center (Memorial Sloan-Kettering Cancer Center vs University of Kentucky Markey Cancer Center). Patients are randomized to 1 of 4 screening arms.

• Arm I (control): Patients complete screening questionnaires about their mood and experience with lung cancer once before and once after a visit with their physician. Neither the patient nor physician receives the screening results before the visit.
• Arm II: Patients complete screening questionnaires as in arm I. Only the patient receives the screening results before their visit with the physician; the physician remains blinded to the results.
• Arm III: Patients complete screening questionnaires as in arm I. Only the physician receives the screening results before their visit with the patient; the patient remains blinded to the results.
• Arm IV: Patients complete screening questionnaires as in arm I. Both physician and patient receive the screening results before the visit.

All patients and physicians are notified of the screening results before the patient leaves the clinic. All patients are offered supportive counseling.

Enrollment: 241 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

• Diagnosis of lung cancer

• Prescreening distress thermometer score > 3

• Zung Self-Rating Depression Scale (ZSDS) score ≥ 44

  • No ZSDS response indicating suicidality

PATIENT CHARACTERISTICS:

• Able to understand English
• No evidence of cognitive dysfunction that would impair giving consent

PRIOR CONCURRENT THERAPY:

• Not specified

Trial design

241 participants in 4 patient groups

Arm I (control)

Experimental group

Description:

Arm I (control): Patients complete screening questionnaires about their mood and experience with lung cancer once before and once after a visit with their physician. Neither the patient nor physician receives the screening results before the visit.

Treatment:

Procedure: psychosocial assessment and care

Other: counseling intervention

Other: screening questionnaire administration

Other: study of socioeconomic and demographic variables

Arm II

Experimental group

Description:

Arm II: Patients complete screening questionnaires as in arm I. Only the patient receives the screening results before their visit with the physician; the physician remains blinded to the results.

Treatment:

Procedure: psychosocial assessment and care

Other: counseling intervention

Other: screening questionnaire administration

Other: study of socioeconomic and demographic variables

Arm III

Experimental group

Description:

Arm III: Patients complete screening questionnaires as in arm I. Only the physician receives the screening results before their visit with the patient; the patient remains blinded to the results.

Treatment:

Procedure: psychosocial assessment and care

Other: counseling intervention

Other: screening questionnaire administration

Other: study of socioeconomic and demographic variables

Arm IV

Experimental group

Description:

Arm IV: Patients complete screening questionnaires as in arm I. Both physician and patient receive the screening results before the visit. All patients and physicians are notified of the screening results before the patient leaves the clinic. All patients are offered supportive counseling.

Treatment:

Procedure: psychosocial assessment and care

Other: counseling intervention

Other: screening questionnaire administration

Other: study of socioeconomic and demographic variables