Descemet Membrane Endothelial Keratoplasty vs. Descemet's Stripping With Endothelial Keratoplasty vs. Descemet Stripping Only

Wake Forest University (WFU)

Status: Terminated

Conditions: Fuchs Dystrophy; Cystoid Macular Edema

Treatments: Diagnostic Test: Optical Coherence Tomography

Study type: Observational

Funder types: Other

Identifiers

NCT04527523

IRB00067948

Details and patient eligibility

About

This study aims to evaluate and compare incidence of post-operative cystoid macular edema (CME) after Descemet Membrane Endothelial Keratoplasty (DMEK), Descemet's Stripping Automated endothelial Keratoplasty (DSEK) and Descemet Stripping Only (DSO).

Full description

Patients that are undergoing any of these procedures will be asked if they are willing to have a baseline pre-operative Optical Coherence Tomography (OCT) scan completed within 4 weeks of surgery. Additional OCT scans will be collected during routine follow up care. It is hypothesized that the rates of CME will be lower with DSO compared to DMEK and DSEK.

Enrollment: 4 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Any patient that is undergoing DSO or endothelial corneal transplantation vis DMEK or DSEK

Exclusion criteria

• Patients that do not have an optical coherence tomography measurement pre- operatively
• Patients that don't have an optical coherence tomography measurement post- operatively
• Patients with a previous history of uncontrolled macular edema

Trial design

4 participants in 1 patient group

Endothelial Dysfunction Cohort

Description:

All patients enrolled in the study will receive a baseline Optical Coherence Tomography scan (OCT) within 4 weeks prior to surgery. Two additional OCT scan will be performed 6 weeks and 3 months after surgery.

Treatment:

Diagnostic Test: Optical Coherence Tomography