Description and Modeling of Swallowing Disorders After a Stroke (AVC-MODE)

Grenoble Alpes University Hospital Center (CHU)

Status: Unknown

Conditions: Stroke; Swallowing Disorders

Treatments: Other: Breathing investigation; Other: Postural investigation; Other: MRI and articulatory investigation; Other: Laryngological evaluation; Other: Voice and soundscape investigation; Other: Neurological evaluation; Other: MRI evaluation

Study type: Observational

Funder types: Other

Identifiers

NCT02974530

2016-A00070-51

Details and patient eligibility

About

The oropharyngeal junction participates in 3 interpenetrating functions: Swallowing, Breathing and Speech. In the context of ischemic or hemorrhagic stroke, these are altered, isolated or associated manner, causing major disorders and representing a source of handicap for patients.

Understanding the swallowing mechanisms is therefore a major challenge to guide the rehabilitation and improve the initial and long-term prognosis of patients with stroke.

The main objective of this study is to describe and modeling, thanks to a clinical, physiological and radiological knowledge base, swallowing, speech and breathing, in patients with stroke and in healthy subjects.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

For patients after stroke

Inclusion Criteria:

• First stroke confirmed by MRI < 15 days
• No severe leukoaraiosis
• Swallowing disorders identified (GUSS scale < 20)
• Neurological deficit identified (NIHSS scale <15)
• Patient able to cooperate for investigations
• Informed consent signed

Exclusion Criteria:

• Cerebral hemorrhage
• History of neurological disease that can lead to swallowing disorders
• History of laryngological disease such as previous surgery or radiation neck
• Tracheotomy
• Vigilance disorders
• Pregnant, parturient or nursing woman
• Protected adult
• Simultaneous participation in another study
• Non registered to the French social security system

For healthy subjects

Inclusion Criteria :

• Age between 18 and 40 years old
• French native speaker
• Normal hearing with or without corrective
• No oral or written language disorders
• No neurological or psychiatric disorders
• Informed consent signed

Exclusion Criteria

• MRI contraindication
• Pregnant, parturient or nursing woman
• Simultaneous participation in another study
• Non registered to the French social security system

Trial design

150 participants in 2 patient groups

Stroke population

Description:

Patient with stroke will be explored during their acute phase and in 6 months of diagnosis.

Treatment:

Other: Postural investigation

Other: Breathing investigation

Other: Laryngological evaluation

Other: Neurological evaluation

Other: Voice and soundscape investigation

Other: MRI evaluation

Healthy population

Description:

Healthy subjects will be explored in Grenoble in research laboratory

Treatment:

Other: Postural investigation

Other: Breathing investigation

Other: Voice and soundscape investigation

Other: MRI and articulatory investigation