Description of Abdominal and Gluteo-femoral Subcutaneous Adipose Tissue Cell Population in Women - GLUTAB

Institut National de la Santé Et de la Recherche Médicale, France

Status

Completed

Conditions

Adipose Tissue

Treatments

Procedure: Biopsies

Study type

Interventional

Funder types

Other

Identifiers

NCT01605578

C11-48

2011-A01496-35 (Registry Identifier)

Details and patient eligibility

About

The purpose of this study is to compare, in healthy women, the adipose tissue composition between abdomen and thigh and then determine whether differences exist independently of the state of obesity.

The findings of this study may help to explain the mechanism contributing to a beneficial role of gluteo-femoral fat contrasting with a deleterious role of abdominal fat on cardiovascular and metabolic dysfunctions.

Enrollment

20 patients

Sex

Female

Ages

25 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

women between 15 and 45 years old
with genital activity
stable weight during the previous 3 months
BMI from 20 to 28
regular menstrual cycles (28 +/- 2 days) during the previous 3 months
reliable means of contraception (systemic hormonal contraception, intrauterine contraceptive device, tubal ligation)
using the same way of contraception during the previous 3 months
normal clinical examination
able to be compliant with the schedule of protocol assessments
willing and able to provide written informed consent
affiliated to a National Health Service
agreeing to being registered on the national file for subjects participating in biomedical research

Exclusion criteria

Exclusions related to significant medical disturbances :
type I and II diabetes
early menopause
serious psychological disorders
uncontrolled thyroid disorders
know allergy to local anesthetics especially Xylocaine
abnormal laboratory results
medical history that, in the opinion of the investigator, makes the subject unsuitable for enrollment
positive test result for HIV, HCV and/or HBV virus
positive pregnancy test
Exclusions related to subject lifestyle :
smoking > 10 cigarettes per day
smoking cessation during the previous 3 months
weight fluctuation (>3kg) during the previous 3 months
alcohol abuse
coffee or tea consumption > 6 cups per day
high consumption of drinks comprising xanthine bases (>0.5 liters/day)
consumption of drinks (water or herbal teas) > 2 liters per day
Exclusions related to previous or concomitant treatments :
anticoagulant
neuroleptic or antidepressant
medication with draining, lipolytic, appetite suppressant and/or slimming effect
local or systemic corticosteroid therapy on the test areas
hormonal treatment other than contraception
diuretic
local treatment against cellulitis (mesotherapy,phosphatidylcholine injection, mechanical process)
thighs liposuction < 2 years
chronic treatment with anti-inflammatory
Exclusions related to the subject :
unwillingness or inability to comply with the requirements of the protocol
previous participation in a clinical trial within 30 days
inability to understand and sign the consent due to linguistic or psychic issues
subject deprived of liberty or under guardianship, tutorship or judicial protection
female who are currently pregnant or breastfeeding or female considering becoming pregnant while in the study