Description of Physical Activity Effect on Neuromuscular Fatigue of Older People (ACTIFS-AGE)

Centre Hospitalier Universitaire de Saint Etienne

Status: Terminated

Conditions: Aging; Fatigue

Treatments: Other: Questionnaires completion; Other: Energy cost; Other: Isometric forces

Study type: Interventional

Funder types: Other

Identifiers

NCT05413590

21CH033

ANSM (Other Identifier)

Details and patient eligibility

About

There is a decrease in cardiovascular and neuromuscular functions, which leads to reduced performance with advancing age. Physical activity provides health benefits, prevents and treats cardiovascular and neuromuscular disease. The aim of this project is to describe cardiovascular and neuromuscular function in active and sedentary subjects of different ages.

Full description

With advancing age, there is a decrease in cardiovascular and neuromuscular functions, which leads to reduced performance and increases the likelihood that older people will lose their independence. Physical activity provides health benefits, prevents and treats cardiovascular and neuromuscular disease. Indeed, recent data support the idea that it is fitness level, not age that explains physiological responses to exercise. However, although there are data about how quickly cardiovascular and neuromuscular functions decline throughout life, less is known on the extent physical activity can help mitigate the loss of these functions. The aim of this project is therefore to describe cardiovascular and neuromuscular function in active and sedentary subjects of different ages.

Enrollment: 93 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged 18 to 35 for the young group, between 65 and 80 for the old group and over 80 for the very old group.
• Signed consent for the study obtained
• Subject affiliated or entitled to a social security scheme

Exclusion criteria

• Pathology or surgical intervention causing a locomotor disorder
• Neurological, cardiovascular or psychological pathology
• Participants will be excluded if resting or exercise ECG responses show any abnormality, or if resting Heart Rate (HR) > 100 bmp, resting blood pressure > 144 (systolic) / 95 (diastolic) mmHg, pulmonary and or cardiac disease that could affect the health of the participant (arrhythmias and stroke)
• Mini-Mental State Examination score < 20 (>80 years old)
• Significant change in the amount of physical practice over the last 5 years.

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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93 participants in 6 patient groups

Young, Active group

Active Comparator group

Description:

From 18 to 35 years old. The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count: * at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR * at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR * At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 Metabolic Equivalent of Task (MET)-minutes per week

Treatment:

Other: Isometric forces

Other: Energy cost

Other: Questionnaires completion

Young, sedentary group

Active Comparator group

Description:

From 18 to 35 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years.

Treatment:

Other: Isometric forces

Other: Energy cost

Other: Questionnaires completion

Old, Active group

Active Comparator group

Description:

From 65 to 80 years old. The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count: * at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR * at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR * At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 MET-minutes per week

Treatment:

Other: Isometric forces

Other: Energy cost

Other: Questionnaires completion

Old sedentary group

Active Comparator group

Description:

From 65 to 80 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years.

Treatment:

Other: Isometric forces

Other: Energy cost

Other: Questionnaires completion

Very old, Active group

Active Comparator group

Description:

From 81 years old. The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count: * at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR * at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR * At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 MET-minutes per week

Treatment:

Other: Isometric forces

Other: Energy cost

Other: Questionnaires completion

Very old sedentary group

Active Comparator group

Description:

From 81 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years.

Treatment:

Other: Isometric forces

Other: Energy cost

Other: Questionnaires completion