Description of Septic Thrombophlebitis on Central Venous Catheter and Midline (THROMBOSEP)

Centre Hospitalier le Mans

Status

Enrolling

Conditions

Septic Thrombophlebitis

Treatments

Diagnostic Test: Doppler ultrasound

Study type

Interventional

Funder types

Other

Identifiers

NCT05743738

CHM-2020/S10/14

Details and patient eligibility

About

Central venous catheters improve the tolerability and feasibility of patient care in the hospital setting by allowing the administration of hyper-osmotic, vesicant and venotoxic fluids. Despite these advantages, the long-term presence of central venous catheters is associated with thrombotic and infectious risks , including catheter-related bacteremia, which can be complicated by septic thrombophlebitis and endocarditis that can lead to death.

Septic thrombophlebitis is a complication of venous catheter infections, which increases the morbidity. It is defined by the presence of a thrombosis in the vein where the venous catheter is located, associated with a bacteremia. A distinction is made between superficial and deep thrombophlebitis.

The frequency of septic thrombophlebitis of venous catheters is variable and poorly described in the literature.

When the diagnosis of septic thrombophlebitis is made, it is recommended to extend the duration of antibiotic therapy, to remove the infected catheter and to prescribe anticoagulant treatment. However, there is no recommendation on the duration of anticoagulation for septic thrombophlebitis, whether it is deep or superficial.

Investigator proposes a prospective and descriptive interventional study to describe the ultrasound evolution of thrombus in patients with septic thrombophlebitis on central venous catheter and midline.

Enrollment

120 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Adult patient hospitalised at the CHM or CHUA, with a central venous device (Implantable chamber, central venous jugular, femoral, subclavian, PICCline, dialysis catheter) or a Midline and having catheter-related bacteremia
Catheter-related bacteremia according to the following definition (ePOPI): Positive blood cultures within 48 hours of a suspected catheter infection (or its removal) With one of the following criteria: - Before catheter removal: differential time of positivity of central/peripheral blood cultures ≥ 2 hours
After catheter removal: positive catheter culture ≥ 103 CFU/ml, with the same organism.
Patient transportable for ultrasound or ultrasound can be performed in the patient's bed
Patient capable of giving consent, or consent of the trusted person for patients not capable of giving consent at the time of inclusion
Written consent signed by the participant and the investigator
Person affiliated to social security

Exclusion criteria