Description of the Interdigitation Retinal Area by SD-OCT: An Exploratory Study (ODIGIT)

Fondation Ophtalmologique Adolphe de Rothschild

Status: Completed

Conditions: Retina; Tomography, Optical Coherence

Treatments: Device: Spectral Domain Optical Coherence Tomography

Study type: Interventional

Funder types: NETWORK

Identifiers

NCT03326908

MMT_2017_16

Details and patient eligibility

About

Improvement of retinal medical imaging opens new perspectives for exploring the retinal structures. Optical coherence spectral domain (SD-OCT), which has been widely used in the last ten years, is certainly the most advanced device. In the analysis of patients without retinal disease using SD-OCT, granulations in the interdigitation area were observed. These granulations have never been described with this device. They could correspond either to the degradation products of the external segments of the photoreceptors or to melanosomes. A descriptive study of these granulations at different examination times and in different lighting situations would allow us to obtain essential information for a better understanding of this area. Based on the results, larger studies could explore this area more finely in retinal pathologies involving dysfunctions of photoreceptors or of the pigmentary epithelium.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patient aged 18 years or older
• Consent to participate

Exclusion criteria

• Retinal abnormalities

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Normal conditions of light exposure

Other group

Description:

Spectral Domain Optical Coherence Tomography (SD-OCT): Five SD-OCTs will be produced under the same lighting conditions (photopic). * At baseline * 20 minutes after baseline * 25 minutes after baseline * 45 minutes after baseline * 60 minutes after baseline

Treatment:

Device: Spectral Domain Optical Coherence Tomography

Light variations

Other group

Description:

Spectral Domain Optical Coherence Tomography (SD-OCT): Five SD-OCT will be performed: * at baseline, in a room with photopic artificial lighting (400 lux) * after a period of adaptation to the dark (20 minutes in the dark: 0 lux) * after 5 min of retinal glare, obtained by means of a projection of light of 1000 lux on the fundus of eye * 15 minutes after this period of retinal glare, in photopic artificial lighting * 30 minutes after the period of retinal glare, in photopic artificial lighting

Treatment:

Device: Spectral Domain Optical Coherence Tomography