Descriptive Analysis of Dual-energy Computed Tomography Exams of Adult Patients With Gout (DECTGOUT)

Assistance Publique - Hôpitaux de Paris

Status: Unknown

Conditions: Gout

Treatments: Diagnostic Test: Dual-energy computed tomography

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT05065606

APHP180476

Details and patient eligibility

About

The main objective is to describe urate deposits (especially in terms of distribution and volume) in soft tissues and bone, and joint erosions and destruction, in adult patients with gout.

Full description

Gout is the result of hyperuricemia, itself a consequence of a disorder of purine metabolism. This hypuricemia can lead to the deposition of sodium urate crystals in the soft tissues. It is the deposition of sodium urate crystals in and near the joints that causes an intense local inflammatory reaction with episodes of acute joint pain, swelling and functional disability. In the long term, uratic concretions in the soft tissues (tophus) occur, the joints are destroyed (uratic arthropathies), the kidneys also (gouty nephropathy).

Dual-energy CT (Computed Tomography) is a relatively recent technique that allows the identification of certain materials through the analysis of the difference in attenuation of the material exposed to two different X-ray spectra. This technique identifies the crystalline component of tophus.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age greater than or equal to 18 years old;
• Patient with a gout according to ACR (American College of Rheumatology) criteria;
• Affiliated with a social security scheme.
• Dual-energy scanner examinations stored in the PACS at Lariboisière Hospital

Exclusion criteria

• Pregnant or breastfeeding woman.