Descriptive and Retrospective Analysis of Acute Myocarditis Associated With Pandemic COVID-19 in Children (HEART-COVID)

Assistance Publique - Hôpitaux de Paris

Status: Completed

Conditions: COVID-19

Study type: Observational

Funder types: Other

Identifiers

NCT04420468

APHP200632

Details and patient eligibility

About

The study objectives are to descript clinical, biological and echocardiographic features of an acute myocarditis in children in the context of COVID-19 and to identify the underlying mechanism : direct viral damage and/or inadequate host response risk.

Full description

An unexpected increase of shock with fever in children suspected to be infect by the COVID-19 is observed. These children present with similar symptoms and seem to have similar clinical time course.

This unexpected phenomenon needs to be extensively described in order to further the knowledge of unusual COVID-19 presentation in children.

The study consists an extensive retrospective data collection from April 2020 till the end of the main SARS-Cov-2 outbreak, from medical file of children have exhibited acute myocarditis and cared in 4 pediatric intensive care units of Assistance Publique-Hôpitaux de Paris of Ile-de-France region.

The study objectives are to descript clinical, biological and echocardiographic features of an acute myocarditis in children in the context of COVID-19 and to identify the underlying mechanism : direct viral damage and/or inadequate host response risk.

Enrollment: 20 patients

Sex: All

Ages: Under 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age < 18 years
• Admitted to PICU from April 2020
• Presented with an acute myocarditis, fever and shock with a possible COVID-19 infection

Exclusion criteria

• Age ≥ 18 years
• Other etiologies of acute myocarditis than the COVID-19
• Opposition expressed by the holders of parental authority

Trial design

20 participants in 1 patient group

Possible COVID-19 infection and acute myocarditis

Description:

Children presented with an acute myocarditis, fever and shock with a possible COVID-19 infection cared between April 2020 till the end of the main SARS-Cov-2 outbreak in 4 AP-HP Parisian hospitals : * Necker-Enfants Malades * Armand Trousseau * Robert Debré * Kremlin Bicêtre