Desflurane and Brain Relaxation in Craniotomy

Capital Medical University

Status: Completed

Conditions: Supratentorial Tumor

Treatments: Drug: Desflurane; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT04691128

H199510180629

Details and patient eligibility

About

Optional brain relaxation improves the surgeon's operating conditions and is likely to minimize the degree of retraction injury ,with the potential for providing patients with a better outcome. The choice of anesthetic drugs can affect intraoperative brain relaxation. Propofol suppresses brain metabolism, reduces cerebral blood flow, and provides satisfactory brain relaxation. Desflurane is often criticized in neurosurgery due to its cerebral vasodilation and potential to increase intracranial pressure, however, it has been found to have a little clinical significance. This study intends to compare the effects of desflurane with propofol on brain relaxation in patients with supratentorial tumors under mild hyperventilation, and to provide new clinical evidence for the use of desflurane in neurosurgical anesthesia.

Full description

To compare the effect of desflurane versus propofol combined with remifentanil anesthesia on brain relaxation in patients undergoing supratentorial tumor surgery with mild hyperventilation, and compare the emergence time and common complications during recovery.

Enrollment: 111 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18-60 years
• Scheduled for elective craniotomy for supratentorial cerebral tumors
• ASA status I-III
• Glasgow score of 15
• No clinical signs of intracranial hypertension
• Preoperative brain imaging (CT or MRI) with midline shift less than 5mm
• Informed consent signed by patients

Exclusion criteria

• Scheduled intraoperative motor evoked potential monitoring
• Patients with cerebral vascular diseases
• Uncontrolled cardiopulmonary disease
• Schedule to retain tracheal intubation after surgery
• Unable to comprehend and cooperate with the examination
• BMI > 30 Kg/m-2
• Emergency surgery
• History of related anesthetic allergy

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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111 participants in 2 patient groups

Desflurane inhalational anesthesia

Experimental group

Treatment:

Drug: Desflurane

Propofol total intravenous anesthesia

Active Comparator group

Treatment:

Drug: Propofol