Desflurane and Postoperative Sleep Quality in Patients Undergoing Elective Breast Surgery

Zhongnan Hospital

Status: Completed

Conditions: Postoperative Sleep; Propofol; Desflurane; Breast Tumor; PSQI

Treatments: Drug: Desflurane Inhalation

Study type: Interventional

Funder types: Other

Identifiers

NCT04805775

B076201420067

Details and patient eligibility

About

This study intends to investigate the effects of desflurane on postoperative sleep quality to guide perioperative patient management.

Enrollment: 118 patients

Sex: Female

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Undergoing elective breast surgery
2. Age 18-75 years old
3. ASA-PS grade I or II
4. Those who voluntarily participate in the research and sign the informed consent

Exclusion criteria

1. Cognitive impairment (MMSE <27) before the operation
2. The patients received adjuvant chemotherapy before the operation
3. At present, they are taking psychoactive, opioid, anti-anxiety, and hypnotic drugs
4. Known or treated patients with obstructive sleep apnea
5. Patients with other cancers

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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118 participants in 2 patient groups

Desflurane Inhalation Group

Experimental group

Description:

Anesthesia maintenance: Desflurane inhalation (MAC 1.0-1.2) Sufentanil 0.3-0.5 μg / (kg·h) Cisatracurium 1-3 μg / (kg·min)

Treatment:

Drug: Desflurane Inhalation

Propofol Group

Active Comparator group

Description:

Anesthesia maintenance: Propofol TCI: 3-4ug / ml Sufentanil 0.3-0.5 μg / (kg·h) Cisatracurium 1-3 μg / (kg·min)

Treatment:

Drug: Desflurane Inhalation