Desflurane and Sevoflurane Minimal Flow Anesthesia on Recovery and Anesthetic Depth

Ufuk University

Status and phase: Unknown; Phase 4

Conditions: Anesthesia

Treatments: Procedure: Minimal flow anesthesia (fresh gas flow <0.5 l/min) using Desflurane; Procedure: Minimal flow anesthesia (fresh gas flow <0.5 l/min) using Sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT05024084

2021-009

Details and patient eligibility

About

Minimal flow anesthesia has economic and environmental advantages in addition to providing earlier recovery following general anesthesia. There is a paucity of data concerning the effect of minimal flow anesthesia (fresh gas flow <0,5 l/min) on recovery parameters. The primary objective of this study is to compare the recovery parameters of desflurane and sevoflurane in minimal flow anesthesia while the secondary objective is to compare the effect of these agents on anesthetic depth using bispectral index.

Enrollment: 130 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ages between 18 and 65
• Patients undergoing elective surgery under general anesthesia
• Patients with an American Society of Anesthesiologists Classification I or II

Exclusion criteria

• Patient refusal
• Emergency surgery
• Patients with a contraindication for minimal flow anesthesia
• Uncontrolled diabetes mellitus
• History of serious systemic disease (cardiac, pulmonary, hepatic)
• Utilization of another analgesic technique such as central or peripheral nerve blocks

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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130 participants in 2 patient groups

Group Sevoflurane

Active Comparator group

Description:

The patients in this arm will be given Sevoflurane (2-3%) as volatile anesthetic throughout the duration of anesthesia.

Treatment:

Procedure: Minimal flow anesthesia (fresh gas flow <0.5 l/min) using Sevoflurane

Group Desflurane

Active Comparator group

Description:

The patients in this arm will be given Desflurane (7-8%) as volatile anesthetic throughout the duration of anesthesia.

Treatment:

Procedure: Minimal flow anesthesia (fresh gas flow <0.5 l/min) using Desflurane