Desflurane and Sevoflurane on Remifentanil Requirement

Ajou University School of Medicine

Status: Not yet enrolling

Conditions: Spinal Diseases

Treatments: Drug: Sevoflurane Inhalation Solution; Drug: Desflurane Inhalation Solution

Study type: Interventional

Funder types: Other

Identifiers

NCT06123624

AJOUIRB-IV-2023-380

Details and patient eligibility

About

The primary purpose of this study is to compare the desflurane and sevoflurane on remifentanil requirement using analgesia nociception index-guided anesthesia in patients undergoing spine surgery.

Enrollment: 78 estimated patients

Sex: All

Ages: 19 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of herniated disc, injury of spinal cord, and neoplasm of spinal meninges

Exclusion criteria

• Hyperbilirubinemia
• Prior chronic pain
• Prior opioid abuse
• Cardiac arrythmia

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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78 participants in 2 patient groups, including a placebo group

Desflurane group

Experimental group

Treatment:

Drug: Desflurane Inhalation Solution

Sevoflurane group

Placebo Comparator group

Treatment:

Drug: Sevoflurane Inhalation Solution