Desflurane Versus Propofol in the Sitting Position

Gachon University Gil Medical Center

Status: Completed

Conditions: Cerebral Ischemia

Treatments: Drug: Rocuronium; Drug: alfentanil; Drug: propofol; Drug: Desflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT01436799

GIRBA2466

Details and patient eligibility

About

The investigators hypothesized that both propofol and desflurane would decrease the regional oxygen saturation (rSO2) but propofol is likely to reduce rSO2 more than sevoflurane when patients are raised to the sitting position.

Full description

The investigators hypothesized that both propofol and desflurane would decrease the rSO2 but propofol is likely to reduce rSO2 more than sevoflurane when patients are raised to the sitting position. Therefore, the purpose of this study was to investigate the effect of desflurane and propofol on rSO2 values during the beach chair position for shoulder arthroscopy.

Enrollment: 40 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Forty patients,
• ASA class I or II,
• undergoing shoulder arthroscopy

Exclusion criteria

• Patients with history of cerebrovascular disease, coronary occlusive disease and/or obesity (body mass index > 30) were excluded from this study.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

Desflurane

Experimental group

Description:

anaesthesia was induced with thiopental sodium 2 mg kg-1, alfentanil 10 μg kg-1 and rocuronium 0.6 mg kg-1. Anesthetic maintenance by desflurane

Treatment:

Drug: Desflurane

Drug: alfentanil

Drug: Rocuronium

propofol

Active Comparator group

Description:

anaesthesia was induced with the effect-site concentration of propofol 5.0 μg ml-1, alfentanil 10 μg kg-1, and rocuronium 0.6 mg kg-1. A commercially available target controlled infusion (TCI) pump (Orchestra®, Fresenius Vial, France) was used and the pharmacokinetic set used to calculate target effect-site concentrations for propofol was Schnider and colleagues' model

Treatment:

Drug: propofol

Drug: alfentanil

Drug: Rocuronium