Desflurane vs. Sevoflurane in Endovascular Aortic Repair

Begoña Quintana Villamandos

Status and phase: Completed; Phase 4

Conditions: Renal Failure

Treatments: Drug: Desflurane; Drug: Sevoflurane

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT03917186

DESEVAR

Details and patient eligibility

About

Randomized Clinical Trial following the evaluation of the impact on renal function in patients undergoing endovascular aortic aneurysm repair with two anesthetics protocols (Desflurane versus Sevoflurane) on the first 24 hours after surgery.

Full description

Randomized Clinical Trial to evaluate the impact on renal function in patients undergoing endovascular aortic aneurysm repair with two anesthetics protocols (Desflurane versus Sevoflurane) on the first 24 hours after surgery.

Secondary Endpoint: Among secondary endpoints we will evaluate clinical variables such emergence and recovery characteristics (time to extubation and time to emergence-open eyes and response to verbal command), the need for postoperative mechanical ventilation, the post-anesthesia recovery score and ICU length of stay.

Enrollment: 80 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• older than 18 years undergoing elective endovascular aortic repair
• who have signed informed consent

Exclusion criteria

• urgent surgery
• with known hypersensitivity to Desflurane or Sevoflurane.
• Renal failure in hemodialysis

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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80 participants in 2 patient groups

Group sevoflurane

Active Comparator group

Description:

Administration under labelling conditions

Treatment:

Drug: Sevoflurane

Group desflurane

Experimental group

Description:

Administration under labelling conditions

Treatment:

Drug: Desflurane