Design and Application of Vitamin D Films for Burn Healing After Cauterizing Surgery

Deraya University

Status and phase: Completed; Early Phase 1

Conditions: Nasal Obstruction

Treatments: Drug: Vitamin D3

Study type: Interventional

Funder types: Other

Identifiers

NCT05142072

Ahmed Ali (Other Identifier)

DNFs

Details and patient eligibility

About

One of this method's drawbacks is the healing of cauterized cartilage after processing. It was reported that the healing is so slow as no dosage form can reach this place in addition to the scares produced from healing is very irritable to the patient.

From this point, the investigators start searching for a solution to this problem and reach the repositioning of Vitamin D3 (calciferol) as an active ingredient for the rapidity and efficacy of burn healing.

The dosage form of choice that was reported before for intranasal application by the same team of investigators and gave good results. the intranasal films were proved for its convince, simplicity, efficacy, and compliance to patients.

Enrollment: 20 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients complain of nasal obstruction
• do not respond to medications
• treatment need surgery
• patients accept following up in a timely manner for 3 weeks

Exclusion criteria

• no nasal polyps,
• have problems with the surgical procedures
• have allergy with any of the treatment components (vitamin D3 or chitosan)
• don't follow instructions or miss the following up

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

vitamin D film

Experimental group

Description:

Prepared intranasal films containing vitamin D3 by the investigators and administered to the right nostril with the aid of an ENT surgeon

Treatment:

Drug: Vitamin D3

control group

Other group

Description:

No devices will be added

Treatment:

Drug: Vitamin D3