Desmopressin for Bleeding Related to Low Body Temperature

The University of Hong Kong (HKU)

Status and phase: Unknown; Phase 4

Conditions: Hypothermia Induced Impairment of Primary Haemostasis

Treatments: Drug: desmopressin; Drug: placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT00902057

UW 09-088

Details and patient eligibility

About

To study, with a prospective randomised controlled design, whether the subcutaneous administration of the haemostatic drug desmopressin, may improve the impairment of primary haemostasis due to mildly decreased temperature.

Enrollment: 48 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Healthy volunteers

Exclusion criteria

1. Any known platelet or coagulation disorder.
2. Pregnant or lactating women.
3. Known chronic liver or renal disease.
4. Coronary artery, carotid artery or peripheral artery disease
5. Recent history of taking antiplatelet drugs, anticoagulants or herbal preparations.
6. Smoker or alcohol user
7. Mentally incapable of providing informed consent
8. Students or junior staff members who had direct working relationship with the PI

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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48 participants in 4 patient groups, including a placebo group

desmopressin 1.5

Active Comparator group

Treatment:

Drug: desmopressin

Drug: desmopressin

Drug: desmopressin

desmopressin 3

Active Comparator group

Treatment:

Drug: desmopressin

Drug: desmopressin

Drug: desmopressin

desmopressin 15

Active Comparator group

Treatment:

Drug: desmopressin

Drug: desmopressin

Drug: desmopressin

placebo

Placebo Comparator group

Treatment:

Drug: placebo