DETECT and Retinal Outcomes in Hypertension

Emory University

Status: Completed

Conditions: Hypertension; Cognitive Impairment; Retinal Disorder

Study type: Observational

Funder types: Other

Identifiers

NCT01815567

IRB00060043

Details and patient eligibility

About

The purpose of this study is to study the impact of blood pressure on cognitive performance.

Full description

Four groups will be evaluated for possible impact of blood pressure on cognitive performance and retinal damage.

Enrollment: 234 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Patients triaged to the Grady Memorial Hospital Emergency Department or Marcus Trauma Unit

2. Age >18 and <65

3. Documented history of hypertension plus one or more of the following:

   • current antihypertensive use with controlled blood pressure
   • elevated Emergency Department systolic blood pressure or diastolic blood pressure
   • OR -

4. Acutely elevated Emergency Department systolic blood pressure or diastolic blood pressure on 2 separate Emergency Department measurements in the absence of a history of hypertension

   • OR -

5. Normal systolic blood pressure or diastolic blood pressure in the absence of hypertension.

Exclusion criteria

1. Non-English speaking
2. Pre-visit cognitive impairment
3. Physical or psychological impairments that would prohibit comprehension and completion of DETECT testing
4. Inability to obtain adequate fundoscopic photos
5. Acute intoxication, altered mental status, or head injury within the last 6 months
6. Opiate or benzodiazepine administration by treating providers
7. Clinical condition not allowing testing.

Trial design

234 participants in 4 patient groups

controlled hypertension

Description:

hypertension with medication controlled

uncontrolled hypertension

Description:

non-controlled hypertension

hypertensive urgency

Description:

hypertensive urgency no previous history or antihypertensives

asymptomatic normotensive

Description:

asymptomatic normotensive control group