Detecting Absence Seizures Using Eye Tracking

Eysz

Status: Completed

Conditions: Epilepsy, Generalized; Seizures; Absence Seizures; Seizure Disorder; Absence Epilepsy

Treatments: Diagnostic Test: Eye movement analysis

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT04439656

DASEY

Details and patient eligibility

About

The goal of this study is to develop a comfortable system that uses a wearable eye-tracker similar to eyeglasses to assist people with epilepsy in counting and measuring the severity of seizures. Participants will wear an eye-tracker during a routine EEG.

Full description

Seizures can be difficult to detect outside of the hospital even with careful observation by a caregiver. EEG is the best method that we have to detect seizures- but it is uncomfortable for long term use outside of the hospital. The goal of this study is to develop a comfortable system that uses a wearable eye-tracker similar to eyeglasses to assist people with epilepsy in counting and measuring the severity of seizures. People participating in this study will have a routine EEG performed while an eye tracker measures eye movements. After the EEG is complete the researchers will compare the eye movements to the EEG to develop a software program that can detect seizures from eye movements.

Enrollment: 150 patients

Sex: All

Ages: 4 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Provision of signed and dated informed consent form- per local IRB

2. Stated willingness to comply with all study procedures including the clicker test and availability for the duration of the study

3. Male or female, aged 4-100

4. Experience known typical absence seizures as defined by the ILAE 2017 classification or referred to EEG lab for staring spell or concern for absence seizure

   a. This will allow for inclusion of children and adults across the entire spectrum of disease states including new diagnosis (medication naive), medication responsive and non-medication responsive

5. Scheduled for clinical EEG observation

Exclusion criteria

1. Intolerant of wearing or unable to wear the eyeglasses
2. Autism or other developmental disorder that the PI thinks will interfere with data collection
3. History of aggression that the PI thinks will interfere with data collection
4. History of not tolerating EEG that the PI thinks will interfere with data collection
5. Unable to give consent (for individuals ≥ 18 years old) unless they have an adult with power of attorney to consent

Trial design

150 participants in 1 patient group

Absence Seizures

Description:

Participants with absence seizures will have their eye movements compared to the EEG recording.

Treatment:

Diagnostic Test: Eye movement analysis