Detecting Early Myocardial Infiltration w/Amyloid & Light Chain Deposition Disease in Multiple Myeloma Subjects

University of Arkansas

Status: Terminated

Conditions: Multiple Myeloma

Treatments: Device: Administering three additional MRI images

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT01018927

110104

Details and patient eligibility

About

The purpose of this study is to see if MRI techniques can be used for early evaluation of cardiac amyloidosis which is sometimes seen in individuals with multiple myeloma. Cardiac amyloidosis is a medical disorder that decreases heart function.

Full description

The purpose is to investigate the use of multiple newer CMR techniques for early evaluation of cardiac amyloidosis in multiple myeloma.

Enrollment: 44 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All races and ethnic groups
• Male and female ages 18-80 years of age
• History of multiple myeloma
• CMR study for evaluation for cardiac amyloidosis

Exclusion criteria

• Pregnant women
• Subject with a metallic or electronic or other device that could be affected by the magnet

Trial design

44 participants in 1 patient group

Additional MRI images

Description:

Prospective review of 100 CMR studies performed on multiple myeloma patients referred for cardiac evaluation by MRI. Three additional MRI images will be performed to determine the role of cardiac MR (CMR) in detecting features of early myocardial infiltration

Treatment:

Device: Administering three additional MRI images