Detecting Lung Infections Through Vibration

University of Florida

Status: Completed

Conditions: Lung Infection

Treatments: Procedure: Phase II Optimal Frequency; Procedure: Group 2 will receive 30 Hz; Procedure: Group 4 will receive 100 Hz; Procedure: Group 3 will receive 60 Hz; Procedure: Group 1 will receive 15 Hz

Study type: Observational

Funder types: Other

Identifiers

NCT02056860

821-2013

Details and patient eligibility

About

The purpose of this study is to test a lung air vibrator device for vibrating air inside the lung. This exploratory diagnostic trial will test a novel and non-invasive means of detecting lower airway infections using exhaled breath sample.

Full description

This study has two phases. Once the subject has consented phase 1 will start by the subject breathing air out of their lungs into the device. Next, the subject will simply breathe through the mouthpiece with the machine turned on and take samples of exhaled air.

In phase 2, the subjects will breathe air out of their lungs into the device for 15 minutes. Next, the subject will simply breathe through the mouthpiece with the machine turned on and take samples of exhaled air for 15 minutes.

Enrollment: 16 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-50

Exclusion criteria

• History of major respiratory compromise (except cystic fibrosis if included within cystic fibrosis cohort)

Trial design

16 participants in 5 patient groups

Group 1 will receive 15 Hz

Description:

Group 1 (n=30), these subjects will receive 10 minutes of High Frequency Oscillation at 15 Hz at .75 cm on day 1. Then will have a 24 hour washout. On day 2 will receive 10 minutes of low Frequency Oscillation at 15 Hz at 1.25 cm.

Treatment:

Procedure: Group 1 will receive 15 Hz

Group 2 will receive 30 Hz

Description:

Group 2 (n=30), these subjects will receive 10 minutes of High Frequency Oscillation at 30 Hz at .75 cm on day 1. Then will have a 24 hour washout. On day 2 will receive 10 minutes of low Frequency Oscillation at 30 Hz 1.25 cm.

Treatment:

Procedure: Group 2 will receive 30 Hz

Group 3 will receive 60 Hz

Description:

Group 3 (n=30), these subjects will receive 10 minutes of High Frequency Oscillation at 60 Hz 2 .75 cm on day 1. Then will have a 24 hour washout. On day 2 will receive 10 minutes of low Frequency Oscillation at 60 Hz at 1.25 cm.

Treatment:

Procedure: Group 3 will receive 60 Hz

Group 4 will receive 100 Hz

Description:

Group 4 (n=30), these subjects will receive 10 minutes of High Frequency Oscillation at 100 Hz at .75 cm on day 1. Then will have a 24 hour washout. On day 2 will receive 10 minutes of low Frequency Oscillation at 100 Hz at 1.25 cm.

Treatment:

Procedure: Group 4 will receive 100 Hz

Phase II Optimal Frequency

Description:

Participants in Phase II will undergo 10 minutes of HFO at the optimal frequency as determined during Phase I.

Treatment:

Procedure: Phase II Optimal Frequency