Detecting SARS-CoV-2 in Tears

University of Minnesota (UMN)

Status: Completed

Conditions: COVID-19; Corona Virus Infection; COVID; SARS-CoV-2

Treatments: Diagnostic Test: Tear Collection

Study type: Observational

Funder types: Other

Identifiers

NCT04526769

OVNS-2020-29066

Details and patient eligibility

About

Purpose:

• To determine the presence of SARS-CoV-2 in tears
• To determine SARS-CoV-2 receptors in tear production system

Full description

This is a prospective case series. NP swab and tear samples will be collected simultaneously from the confirmed or suspected COVID-19 patients. The samples will be transferred to the lab for SARS-CoV-2 testing. The presence of absence of SARS-CoV-2 will be compared in tears versus NP swabs.

The second part of the study is a histopathology examination series. Normal lacrimal gland and ocular surface tissue samples already stored at the UMN ocular pathology lab and Lion's Gift of Sight Eye Bank will be used for IHC staining for ACE2 and similar targets.

Enrollment: 7 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients presenting at study sites with confirmed or suspected COVID-19

Exclusion criteria

• Pregnancy or nursing
• non-English speakers
• Those unable to read
• Those in other vulnerable study populations

Trial design

7 participants in 1 patient group

COVID-19 Patients

Description:

All patients aged 18 years and above who present to Fairview/UMN ERs or ICUs with confirmed or suspect COVID-19 based on the attending physician's judgment will be included.

Treatment:

Diagnostic Test: Tear Collection