Detecting the Rest Tremor Associated With Parkinson's Disease Using Analysis of the Muscle Contractions Rhythmicity (TREMORHYTHM)

Henri Mondor University Hospital

Status: Enrolling

Conditions: Movement; Abnormal, Involuntary; Rest Tremor; Cerebellar Tumor; Parkinson; Diagnoses Disease

Treatments: Diagnostic Test: EMG in wrist flexor-pronators and extensor-supinators

Study type: Observational

Funder types: Other

Identifiers

NCT05998486

ARM-Tremor

Details and patient eligibility

About

Resting tremors associated with Parkinson's disease (PD) remains difficult to quantify and track during disease progression. This study propose to explore the rhythmicity of distal muscle contractions in the upper limb to characterize resting tremor and discriminate it from cerebellar tremor (CT) based on the frequency spectrum of the EMG signal.

Full description

This retrospective study analyzed surface EMG recordings of wrist flexor-pronators and extensor-supinators from patients with PD or CT bilaterally in five 10-second conditions: rest with contralateral motor distraction, symmetrical arms extended forward posture with hands pronated, semi-pronation, supination, and elbows flexed with hands pronated. The rhythmicity index (RI) is calculated from the ratio of the area of the maximum power peak to the total area of the spectrum between 1.5-12Hz.

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators in Laboratories;
• diagnosis of Parkinson's disease or cerebellar tremor.

Exclusion criteria

• Botulinium toxin injection in upper limb during a delay of 3 months before surface EMG recordings;
• Levodopa drugs administrated during a delay of 12 hours before surface EMG recordings;
• Tremor-favour drugs administrated during a delay of 30 days before surface EMG recordings;
• Presence of an other neurologic disease or of any disease associated with motor disorders in upper limb.

Trial design

80 participants in 2 patient groups

Tremor of rest

Description:

Patient with a diagnosis of Parkinson's disease and who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators analysis in Laboratories

Treatment:

Diagnostic Test: EMG in wrist flexor-pronators and extensor-supinators

Cerebellar tremor

Description:

Patient with a diagnosis of cerebellar tremor and who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators analysis in Laboratories

Treatment:

Diagnostic Test: EMG in wrist flexor-pronators and extensor-supinators