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Detection and Characteristic of Whipple Diseases in the Great Britany (WHO)

R

Regional University Hospital Center (CHRU)

Status

Completed

Conditions

Whipple Disease

Study type

Observational

Funder types

Other

Identifiers

NCT03350685
WHO (29BRC17.0179)

Details and patient eligibility

About

Whipple's disease is a chronic systemic infection caused by ubiquitous bacterium Tropheryma wipplei on a genetic predisposition which should be considered in patients with recurrent episodes of seronegative arthritis, erosive or not, or inflammatory low back pain, chronic diarrhea, persistent fever, unexplained neurological signs, uveitis, endocarditis, and epithelioid granuloma.

Laboratory tests may show malabsorption, erythrocyte sedimentation rate and C-reactive protein elevation, anemia, thrombocytosis, eosinophilia and lymphopenia.

None of theses findings is specific and most patients have arthritis or low back pain mimicking rheumatoid arthritis and spondyloarthritis.

As the disease is rare, chance for positive polymerase chain reaction testing for Tropheryma whipplei is low in this context.

Enrollment

267 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Adult
  • patient with at least a screening test for Whipple'disease
  • participation agreement,

Exclusion criteria

  • No test for Whipple'disease

Trial design

267 participants in 3 patient groups

Classic Whipple's disease (CWD)
Description:
Classic Whipple's disease (CWD), defined as * duodenal biopsy positive by PAS/immunohistochemistry * or blood positive by PCR
Focal Whipple's disease (FWD)
Description:
Focal Whipple's disease (FWD), defined as * joint fluid positive by PCR * but duodenal biopsy negative by PAS/immunohistochemistry
Chronic T. whipplei-associated arthritis (CTWA)
Description:
Chronic T. whipplei-associated arthritis (CTWA) defined as chronic arthritis and * duodenal biopsy, stool, or saliva positive by PCR * duodenal biopsy negative by PAS/immunohistochemistry * joint fluid negative by PCR

Trial contacts and locations

8

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Data sourced from clinicaltrials.gov

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