Detection and Neurological Impact of CerebroVascular Events In Noncardiac Surgery PatIents: A COhort EvaluatioN (NeuroVISION)

McMaster University

Status: Completed

Conditions: Covert Postoperative Stroke

Study type: Observational

Funder types: Other

Identifiers

NCT01980511

NeuroVISION v4.0

Details and patient eligibility

About

The NeuroVISION Study will characterize the incidence, impact, and risk factors of covert stroke in adults undergoing noncardiac surgery. We will determine the incidence of acute covert stroke using an MRI study of the brain in the days following noncardiac surgery. We will characterize the epidemiology and the impact of covert stroke in patients undergoing noncardiac surgery, and its association with cerebral deoxygenation.

Full description

At the University of Wisconsin a planned sub study of NeuroVISION is being conducted aiming to enroll 100 patients with additional cognitive testing, MRI sequences and a preoperative MRI scan.

At Hamilton Juravinski Hospital, Hamilton General Hospital, Auckland City Hospital and Prince of Wales Hospital a planned sub study of NeuroVISION (PAFS - Perioperative Atrial Fibrillation and Postoperative Stroke) is being conducted aiming to enroll 400 participants. The purpose of this sub-study is to determine the prevalence of AF(Atrial Fibrillation) before surgery (i.e. "background" AF), as well of the incidence of AF after surgery using the Icentia CardioSTAT "patch-like" single lead heart rhythm monitor.

Enrollment: 1,116 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥65 years old
• An anticipated hospital stay of at least 2 days after elective noncardiac surgery that occurs under general or neuraxial anesthesia
• Written informed consent for potential participation prior to noncardiac surgery

Exclusion criteria

• Contraindication to MRI (e.g. implanted devices not safe for MRI studies, claustrophobia)
• Unable or unwilling to attend the follow-up appointments
• Documented history of dementia
• Residing in a nursing home
• Undergoing carotid artery surgery or intracranial surgery
• Unable to complete neurocognitive testing due to language, vision or hearing impairment
• Unable to communicate with the research staff due to language barriers
• Patients who do not undergo their research MRI study after surgery
• Patients who do not complete a baseline MoCA questionnaire
• Patients who suffer an acute overt clinical stroke after the index surgery, but before their research MR study
• Previously enrolled in the NeuroVISION Study.