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Detection, Education, Research and Decolonization Without Isolation in Long-term Care Facilities (DERAIL_MRSA)

N

NorthShore University HealthSystem

Status

Completed

Conditions

Methicillin Resistant Staphylococcus Aureus

Treatments

Drug: Decolonization

Study type

Observational

Funder types

Other
Other U.S. Federal agency

Identifiers

NCT01302210
AHRQ 1R18HSO19968-01

Details and patient eligibility

About

Our hypothesis for the DERAIL MRSA program is that one can safely remove the colonization risk from nearly all residents (patients) in a way that does not interfere with the desired life-style for persons in these facilities and thereby reduce the risk of infection and lower the cost of care by avoiding preventable disease.

Full description

The primary endpoint will be measuring the reduction in MRSA colonization prevalence (percentage rate) in the intervention arm as compared to the control arm. One secondary endpoint is to compare the rate of MRSA disease (number of infections per 1,000 patients and 10,000 patient days) in the intervention and control arms. The other secondary endpoint is to determine the cost of MRSA screening and decolonization and compare it to the cost of MRSA disease treatment (both medication cost and the expense of any needed hospitalization for therapy of MRSA infection therapy) in the control arm. Achieving our primary goal of MRSA control will also demonstrate two secondary goals wthe investigators aim to achieve: one being that a scientific, planned approach to the issue of specific healthcare-associated infection in LTCFs can resolve these problems and the other that a partnership between acute and long-term care (e.g., ongoing relationship spanning at least 5 years) is beneficial in dealing with patient safety and quality practices across the United Sates Healthcare continuum.

Enrollment

22,302 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • All patients in 18 LTCF nursing units randomly selected as intervention or control units

Exclusion criteria

  • Patients that choose not to be included in the program

Trial design

22,302 participants in 2 patient groups

Intervention
Description:
Active surveillance testing for MRSA and decolonization of positive subjects
Treatment:
Drug: Decolonization
control
Description:
Usual standard of care

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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