Detection of Chemotherapy Induced Cardiotoxicity

George Washington University (GW)

Status: Completed

Conditions: Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT00636844

JL-001

Details and patient eligibility

About

To identify patients that are at risk of heart damage after receiving chemotherapy (adriamycin).

Full description

To identify patients at risk of development of heart damage after receiving chemotherapy by obtaining the genetic profile of those who show: elevation of troponin, left ventricular systolic and diastolic dysfunction, and pro-oxidant stress markers.

Enrollment: 36 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• undergoing anthracycline and/or trastuzumab therapy for the first time

Exclusion criteria

• abnormal ventricular ejection fraction
• past history of, or active cardiac disease including: MI, CHF, angina, arrhythmia requiring medication, valvular disease, uncontrolled systemic hypertension

Trial design

36 participants in 1 patient group

Group A

Description:

Patients receiving chemotherapy (anthracycline and/or adjuvant trastuzumab) for the first time