Detection of CTC and ctDNA in the Diagnosis of Metastasis in Gastric Cancer (CTC_ctDNA)

China Medical University

Status: Unknown

Conditions: Metastasis; Stomach Neoplasms

Treatments: Diagnostic Test: ctDNA test; Diagnostic Test: CTC test

Study type: Observational

Funder types: Other

Identifiers

NCT05208372

FirstHCMU_CTC_ctDNA

Details and patient eligibility

About

To investigate the value of CTCs and ctDNA in the diagnosis of metastasis in ascites/peritoneal flushing fluid and blood; To investigate the influence of laparoscopic CO2 pneumoperitoneum establishment on peritoneal and hematogenous metastasis of advanced gastric cancer; To explore the influence of the number and type of CTCs and ctDNA on metastasis and prognosis.

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 79 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients who sign informed consent.
2. Gastric cancer is determined by more than 2 pathologists.
3. Patients with Borrmann III/IV gastric cancer.

Exclusion criteria

1. Patients who complicate with other malignant tumors.
2. Patients who complicate with other serious heart and lung diseases.
3. Patients who receive preoperative neoadjuvant chemotherapy.

Trial design

200 participants in 2 patient groups

Laparotomy group

Description:

Patients who undergo radical laparotomy for gastric cancer.

Treatment:

Diagnostic Test: CTC test

Diagnostic Test: ctDNA test

Laparoscopy group

Description:

Patients who undergo laparoscope-assisted radical gastrectomy for gastric cancer.

Treatment:

Diagnostic Test: CTC test

Diagnostic Test: ctDNA test