Detection of Subclinical Cerebral Suffering Related to Hypertension Using Multimodal MRI (SOUCHY)

Toulouse University Hospital

Status: Enrolling

Conditions: Hypertension

Treatments: Diagnostic Test: neuropsychological assessment; Diagnostic Test: blood test; Diagnostic Test: multimodal magnetic resonance imaging

Study type: Interventional

Funder types: Other

Identifiers

NCT04642586

RC31/19/0055

Details and patient eligibility

About

Investigators propose here to study the brain consequences of hypertension in patients without cognitive complaints and neurological signs. The evaluation of brain suffering requires considering various possible brain damage. The team developed a multimodal MRI approach capable of detecting and quantifying numerous indices (e.g. morphometric, microstructural) to evaluate possible brain suffering. This project aims to identify individually signs of cerebral suffering in hypertensive patients compared to a population of normotensive volunteers, using advanced multiparametric MRI methods.

Full description

Hypertension is a risk factor for many brain pathologies, such as ischemic and hemorrhagic neurodegenerative diseases or stroke. The literature seems to agree on the relationship between hypertension and brain damage, and on the benefit of the management of hypertension to prevent certain neurological pathologies. However, to our knowledge, no single study has shown signs of subclinical brain damage in patients with hypertension. At present, no brain MRI is recommended in these patients. In the present study, hypertensive and normotensive patients will undergo a neurological exam, a neuropsychological exam, a biological exam and a MRI exam to individually identify signs of cerebral suffering.

Enrollment: 40 estimated patients

Sex: All

Ages: 35 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male and female 35 to 50 y.o.;for patients: diagnosed HTA within 5 years, treated or confirmed by Ambulatory Blood Pressure Measure;
• For normotensive participants:Absence of HTA confirmed by Ambulatory Blood Pressure Measure

Exclusion criteria

• Known neurological history, stroke, symptomatic headache, long-term use of neuroleptic, tricyclic, MAOI, anti-serotonergic antidepressant medications, diabetes mellitus, treated dyslipidemia, body mass index greater than 30 kg / m, participants who smoked or smoked more than 10 packs-year, MRI contraindication ;
• For HTA patients only: Renal artery dysplasia responsible for hypertension, clinical Cushing Syndrome.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

Hypertensive participants

Experimental group

Description:

diagnosed HTA within 5 years, treated or confirmed by Ambulatory Blood Pressure Measure;

Treatment:

Diagnostic Test: neuropsychological assessment

Diagnostic Test: multimodal magnetic resonance imaging

Diagnostic Test: blood test

Normotensive participants

Experimental group

Description:

absence of HTA confirmed by Ambulatory Blood Pressure Measure

Treatment:

Diagnostic Test: neuropsychological assessment

Diagnostic Test: multimodal magnetic resonance imaging

Diagnostic Test: blood test