Detection of Vascular Injury in Diabetes Through Eye and Nailfold Data (DIVIDEND) - A Pilot Study

John Hunter Hospital

Status: Completed

Conditions: Type 1 Diabetes Mellitus

Treatments: Procedure: Video Nailfold Capillaroscopy; Procedure: Laser Doppler Flowmetry; Device: Ambulatory 24 hr Blood Pressure Monitoring; Procedure: Fundoscopy of eyes

Study type: Observational

Funder types: Other

Identifiers

NCT01279928

HNEHREC 09/04/15/5.10

Details and patient eligibility

About

This project aimed to explore novel methods of detecting small blood vessel disease in a paediatric population with type 1 diabetes mellitus. To do this the techniques of Nailfold capillaroscopy, laser Doppler flowmetry, retinal (eye) vessel analysis and 24-hr Ambulatory Blood Pressure Monitoring were used. Each of these techniques investigated different areas of small blood vessels around the body.

It was hypothesized that in a paediatric population with type 1 diabetes mellitus the novel investigations would be associated with small blood vessel disease and that widespread changes to these blood vessels would be detected through associations between the different novel investigations.

Enrollment: 26 patients

Sex: All

Ages: 8 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 8-18 years old
• Have a diagnosis of type 1 diabetes mellitus

Exclusion criteria

• < 8 years or > 18 years old
• Significant autoimmune rheumatological disease (e.g. lupus or dermatomyositis)

Trial design

26 participants in 1 patient group

Type 1 Diabetes Paediatric

Description:

Paediatric patients aged 8-18 with diagnosed Diabetes Mellitis Type 1 attending paediatric clinic at John Hunter Hospital.

Treatment:

Device: Ambulatory 24 hr Blood Pressure Monitoring

Procedure: Video Nailfold Capillaroscopy

Procedure: Fundoscopy of eyes

Procedure: Laser Doppler Flowmetry