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Detection of Vascular Injury in Diabetes Through Eye and Nailfold Data (DIVIDEND) - A Pilot Study

J

John Hunter Hospital

Status

Completed

Conditions

Type 1 Diabetes Mellitus

Treatments

Procedure: Video Nailfold Capillaroscopy
Procedure: Laser Doppler Flowmetry
Device: Ambulatory 24 hr Blood Pressure Monitoring
Procedure: Fundoscopy of eyes

Study type

Observational

Funder types

Other

Identifiers

NCT01279928
HNEHREC 09/04/15/5.10

Details and patient eligibility

About

This project aimed to explore novel methods of detecting small blood vessel disease in a paediatric population with type 1 diabetes mellitus. To do this the techniques of Nailfold capillaroscopy, laser Doppler flowmetry, retinal (eye) vessel analysis and 24-hr Ambulatory Blood Pressure Monitoring were used. Each of these techniques investigated different areas of small blood vessels around the body.

It was hypothesized that in a paediatric population with type 1 diabetes mellitus the novel investigations would be associated with small blood vessel disease and that widespread changes to these blood vessels would be detected through associations between the different novel investigations.

Enrollment

26 patients

Sex

All

Ages

8 to 18 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • 8-18 years old
  • Have a diagnosis of type 1 diabetes mellitus

Exclusion criteria

  • < 8 years or > 18 years old
  • Significant autoimmune rheumatological disease (e.g. lupus or dermatomyositis)

Trial design

26 participants in 1 patient group

Type 1 Diabetes Paediatric
Description:
Paediatric patients aged 8-18 with diagnosed Diabetes Mellitis Type 1 attending paediatric clinic at John Hunter Hospital.
Treatment:
Device: Ambulatory 24 hr Blood Pressure Monitoring
Procedure: Video Nailfold Capillaroscopy
Procedure: Fundoscopy of eyes
Procedure: Laser Doppler Flowmetry

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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