Determinants of Bone Dimensional Changes After Extraction and Alveolar Ridge Preservation

Marquette University

Status: Not yet enrolling

Conditions: Wound Healing; Tooth Extraction Site Healing; Alveolar Bone Grafting; Bone Healing

Treatments: Other: observational study

Study type: Observational

Funder types: Other

Identifiers

NCT06624982

HR-4787

Details and patient eligibility

About

The main purpose of the study is to measure and localize immediate post extraction changes i.e. socket expansion versus no width change along the socket wall and identify whether the immediate post-extraction ridge width condition (expansion or no change) is a determinant of buccolingual ridge width and height changes 4 months following extraction and ridge preservation.

Full description

The null hypothesis for this study is that there is no difference in bone ridge width and height changes 4 months following extraction and alveolar ridge preservation at sites that undergo immediate post-extraction socket expansion or no immediate post-extraction ridge width change. Patients of the Graduate Periodontics Clinic at Marquette University School of Dentistry scheduled for extraction, bone graft and resorbable membrane will be recruited for this study.

After providing informed consent and prior to local anesthesia and extraction, the following parameters will be recorded: age, gender, race, medical history, medications, tooth site, reason for extraction and tooth mobility. Gingival width will be recorded prior to local anesthesia and extraction, and at 4 months. Gingival thickness will be recorded after local anesthesia and prior to extraction, and at 4 months. Buccolingual ridge width and ridge height will be recorded immediately before, immediately after extraction, and at 4 months. Immediately after extraction, the following measurements will be recorded: buccal bone thickness, number of roots, root length and width, instruments used for extraction, need for flap elevation, duration of extraction, anesthetic amount, type and approach, and operator experience.

Enrollment: 160 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adult patients (18-75 years)
• Good general health (controlled conditions)
• Controlled periodontal disease
• Scheduled for single tooth extraction with bone graft placement and resorbable membrane
• Tooth to be extracted must have adjacent teeth
• Socket wall integrity

Exclusion criteria

• Smoking
• Pregnancy
• Active periodontal disease
• Systemic conditions that affect healing
• Lack of socket wall integrity (bone loss ≥50 %) prior to extraction, teeth with severe infection requiring pre-extraction antibiotic treatment to control infection), and contraindications for tooth extraction.

Trial design

160 participants in 4 patient groups

Non-molar sites with immediate post-extraction ridge expansion

Description:

Non-molar sites with an increase of buccolingual bone width immediately after tooth extraction compared to pre-extraction.

Treatment:

Other: observational study

Non-molar sites with no immediate post-extraction ridge width change

Description:

Non-molar sites without a change in buccolingual bone width immediately after tooth extraction compared to pre-extraction.

Treatment:

Other: observational study

Molar sites with immediate post-extraction ridge expansion

Description:

Molar sites with an increase of buccolingual bone width immediately after tooth extraction compared to pre-extraction.

Treatment:

Other: observational study

Molar sites with no immediate post-extraction ridge width change

Description:

Molar sites without a change in buccolingual bone width immediately after tooth extraction compared to pre-extraction.

Treatment:

Other: observational study