Determinants of Depression and Its Impact on Quality of Life in Patients With Chronic Pancreatitis

Asian Institute of Gastroenterology, India

Status: Completed

Conditions: Chronic Pancreatitis; Quality of Life; Chronic Pain; Depression

Treatments: Other: Patient education about chronic pancreatitis.

Study type: Observational

Funder types: Other

Identifiers

NCT04867304

AIG-DEPCP-01

Details and patient eligibility

About

Chronic pancreatitis (CP) is associated with recurrent intractable abdominal pain, pancreatic exocrine insufficiency and endocrine dysfunction. Very few studies had evaluated the quality of life in CP, and even a fewer have assessed the mental status in these patients.

In the current study, we proposed to evaluate the the relationship between pain, quality of life and depression status in two large independent cohorts of patients with CP. We also proposed to evaluate the brain metabolites in the right and left anterior cingulate cortex, basal ganglia, hippocampus and prefrontal cortex using magnetic resonance spectroscopy. We further proposed to evaluate the pasta metabolites and look for associations with the mental state. Finally, we proposed to evaluate how CP related education of the patients could impact on their mental status and response to interventions on pain.

Enrollment: 625 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

A. Inclusion Criteria:

• Age 18-60yrs
• Both genders
• Documented CP for at least 3 years
• Capable and willing to provide informed consent

B. Exclusion Criteria:

• Acute exacerbation of pancreatitis
• Pancreatic malignancy
• On anti-depressant and antipsychotic medications
• Concomitant psychiatric illness (other than depression)
• Pancreatic malignancy
• Major co-morbidities
• Pregnancy and lactation

Trial design

625 participants in 3 patient groups

Healthy controls

Description:

Individuals without any known illnesses and normal labs./USG w/a. This group was used to compare baseline depression, magnetic resonance spectroscopy and plasma metabolites.

Chronic pancreatitis without depression

Description:

This group contains patients with CP who does not have depression based on the Beck Depression inventory.

Treatment:

Other: Patient education about chronic pancreatitis.

Chronic pancreatitis with depression

Description:

This group contains patients with CP who has depression based on the Beck Depression inventory.

Treatment:

Other: Patient education about chronic pancreatitis.