Determinants of Disease Severity in Amyotrophic Lateral Sclerosis

National Institutes of Health (NIH)

Status: Unknown

Conditions: Amyotrophic Lateral Sclerosis

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00004457

199/13650

MGH-97-7231

MGH-1K08NS01896

Details and patient eligibility

About

OBJECTIVES:

I. Determine specific clinical features, molecular abnormalities, and laboratory-based biological markers of free radical stress that are associated with amyotrophic lateral sclerosis and influence disease severity.

Full description

PROTOCOL OUTLINE: This is a screening and diagnostic study. Blood and urine samples are collected from patients every 2 months for 1 year. All samples are evaluated for measures of free radical damage and levels of the body's own antioxidant activity.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

PROTOCOL ENTRY CRITERIA:

--Disease Characteristics-- Clinically diagnosed probable or definite, sporadic or familial amyotrophic lateral sclerosis

--Patient Characteristics-- Pulmonary: No artificial ventilation required Other: No other neurodegenerative diseases No concurrent or history of unstable medical illness