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Determinants of Disease Severity in Amyotrophic Lateral Sclerosis

National Institutes of Health (NIH) logo

National Institutes of Health (NIH)

Status

Unknown

Conditions

Amyotrophic Lateral Sclerosis

Study type

Observational

Funder types

Other
NIH

Identifiers

NCT00004457
199/13650
MGH-97-7231
MGH-1K08NS01896

Details and patient eligibility

About

OBJECTIVES:

I. Determine specific clinical features, molecular abnormalities, and laboratory-based biological markers of free radical stress that are associated with amyotrophic lateral sclerosis and influence disease severity.

Full description

PROTOCOL OUTLINE: This is a screening and diagnostic study. Blood and urine samples are collected from patients every 2 months for 1 year. All samples are evaluated for measures of free radical damage and levels of the body's own antioxidant activity.

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

PROTOCOL ENTRY CRITERIA:

--Disease Characteristics-- Clinically diagnosed probable or definite, sporadic or familial amyotrophic lateral sclerosis

--Patient Characteristics-- Pulmonary: No artificial ventilation required Other: No other neurodegenerative diseases No concurrent or history of unstable medical illness

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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