Determinants of Medical and Surgical Treatment Outcomes in Chronic Sinusitis

Oregon Health & Science University (OHSU)

Status

Completed

Conditions

Chronic Rhinosinusitis

Study type

Observational

Funder types

Other

NIH

Identifiers

NCT01332136

2R01DC005805

Details and patient eligibility

About

This research study will be completed by enrolling a prospective, observational cohort study to evaluate medical versus surgical treatment outcomes for chronic sinus disease. This investigation will compare quality of life outcomes between each treatment type, as well as measure cellular and molecular markers of inflammation in the sinus mucosa, to create models that predict improvement in quality of life following treatment.

Enrollment

966 patients

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Adult (>= 18 years)
Chronic rhinosinusitis as defined by the 2007 multi-disciplinary adult sinusitis guidelines
Able to complete all surveys/questionnaires in English
Persistent symptoms following initial medical management
Received at least 1 course of broad spectrum antibiotics or culture directed antibiotics for at least a total of 14 days
Received at least a 3 week trial of topical steroid sprays OR at least a 5 day trial of systemic corticosteroid therapy.
Counseled for subsequent treatment options including either medical management or endoscopic sinus surgery

Exclusion criteria