Determinants of Muscle Strength in Chronic Kidney Disease

University Hospital Center (CHU)

Status: Completed

Conditions: Chronic Kidney Disease

Treatments: Device: Handheld dynamometer; Other: "Voorrips" score questionnaire; Device: Electrical bioimpedance analysis; Biological: Inflammatory and nutritional status; Biological: Creatinine index

Study type: Interventional

Funder types: Other

Identifiers

NCT02806089

UF9639

Details and patient eligibility

About

Aim of this study is to determine in chronic kidney disease patients:

• the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle strength impairment
• the relationship between voluntary muscle strength and muscle mass
• the relationship between voluntary muscle strength and lean body mass
• the correlation between voluntary muscle strength and physical activity

Full description

Aim of this study is to determine in chronic kidney disease patients:

• the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle strength impairment (estimated by handheld dynamometer)
• the relationship between voluntary muscle strength and muscle mass (estimated by creatinine index)
• the relationship between voluntary muscle strength and lean body mass (estimated by bioelectrical impedance analysis)
• the correlation between voluntary muscle strength and physical activity (the physical activity being estimated by the "Voorrips" score questionnaire)

Enrollment: 110 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• chronic kidney disease patient with extrarenal replacement therapy by hemodialysis for at least 3 months
• stable clinical condition (absence of infection, stroke or acute decompensation)

Exclusion criteria

• chronic kidney disease without extrarenal replacement therapy
• history of renal transplantation

Trial design

Primary purpose: Supportive Care

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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110 participants in 1 patient group

Muscle strength

Experimental group

Description:

single evaluation (the day of inclusion) of muscle strength (by handheld dynamometer), muscle mass (by creatinine index estimation), lean body mass (by electrical bioimpedance analysis), physical activity (by "Voorrips" score questionnaire), inflammatory and nutritional status.

Treatment:

Biological: Inflammatory and nutritional status

Other: "Voorrips" score questionnaire

Device: Electrical bioimpedance analysis

Biological: Creatinine index

Device: Handheld dynamometer