Determinants of Vasospasm and Delayed Ischemic Deficits in Aneurysmal Subarachnoid Hemorrhage

Toulouse University Hospital

Status: Completed

Conditions: Ischemia

Treatments: Procedure: CerebroSpinal fluid and plasma samples

Study type: Interventional

Funder types: Other

Identifiers

NCT02829398

Local Grant (Other Grant/Funding Number)

07 304 02

Details and patient eligibility

About

The risk of delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) is associated with large cerebral artery vasospasm, but vasospasm is not a strong predictor for DCI. Assessment of cerebral autoregulation with transcranial Doppler (TCD) may improve the prediction of DCI. The aim of this prospective study was to assess the value of TCD-derived variables to be used alone or in combination for prediction of DCI

Enrollment: 41 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Group 1 : • Patients who presented a ruptured aneurysm by aneurysmal subarachnoid hemorrhage (SAH) older than 72 hours. Diagnosis of SAH was confirmed by computed tomography, magnetic resonance imaging (MRI) or lumbar puncture as recommended

• symptomatic aneurysm treated with endovascular,
• Absence of achieving a lumbar puncture,
• Patients affiliated to a social security scheme,
• Patients who have given their free and informed consent and signed the consent or consent of the family.

Group 2 :

healthy volunteers with cerebrospinal fluid sample

Exclusion criteria

• Patients with no readable acoustic temporal bone window
• Patients with previous disease that might impair cerebral autoregulation (e.g., carotid stenosis, history of stroke or head injury).

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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41 participants in 2 patient groups

Patients with subarachnoid hemorrhage

Experimental group

Description:

Patients with subarachnoid hemorrhage will have CerebroSpinal fluid and plasma sample.

Treatment:

Procedure: CerebroSpinal fluid and plasma samples

Control subjects

Active Comparator group

Description:

healthy controls from a previous study with a CerebroSpinal fluid and plasma sample

Treatment:

Procedure: CerebroSpinal fluid and plasma samples