Determination of Adipocyte Parameters in Iliac Crest Biopsies From Post Menopausal Women

Mayo Clinic

Status: Completed

Conditions: Osteoporosis; Postmenopausal

Treatments: Drug: estrogen

Study type: Interventional

Funder types: Other

Identifiers

NCT00443716

05-004111

21b85

Details and patient eligibility

About

To evaluate the effect of estrogen treatment on adipocytic and osteoblastic parameters by histomorphometrically measuring adipocyte volume (AV/TV) and adipocyte numbers in goldner's stained iliac crest bone biopsy specimens collected from subjects recruited in the study (IRB number 21B85). The adipocytic parameters will be then correlated with osteoblastic parameters obtained previously during the course of the initai study involving the effect of transdermal estrogen on bone turnover in postmenopausal osteoporotic women.

Sex: Female

Ages: 30+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Post-menopausal osteoporotic women

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)