Determination of Adipocytokine in Synovial Fluid of Osteoarthritis Patients

Parc Taulí Hospital Universitari

Status: Unknown

Conditions: Osteoarthritis

Treatments: Other: ultrasonography of the knee; Other: arthrocentesis

Study type: Observational

Funder types: Other

Identifiers

NCT01993342

Joan03

Details and patient eligibility

About

The purpose of this study is to determine the concentration of different adipocytokine (adiponectin, leptin, resistin, visfatin, osteopontin) and an inflammation classic markers as Interleukine 1 beta, tumor necrosis alfa, interleukine 6 and high sensibility reactive c protein in the synovial fluid of knee osteoarthritis patients, and compare with the inflammation detected with ultrasonography evaluation of the joint. In last years, some studies appeared focusing on the role of adipocytokines in osteoarthritis and they correlated adipocytokines with cartilage degradation and x-ray degree; in our study we will focused in the importance of adipocytokines in the inflammatory changes more than in joint destruction.

Enrollment: 35 estimated patients

Sex: All

Ages: 50 to 81 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• aged 50 to 81
• primary osteoarthritis of the knee
• synovial effusion in examination
• patient who have the results in our database

Exclusion criteria

• any other rheumatic conditions as rheumatoid arthritis or another inflammatory disease
• secondary knee osteoarthritis
• history of knee surgery
• any conditions that at investigator criteria exclude the patient from study procedures

Trial design

35 participants in 1 patient group

Inflammatory knee osteoarthritis

Description:

We recruited patients with osteoarthritis and synovial effusion to diagnostic the effusion and to confirm that this this synovial fluid had mechanical characteristics. Now we are going to determine the adipocytokines and traditional parameters of inflammation in this synovial fluid to correlate it, and we will associate it with the ultrasound explanation of the knee that we have in our database.

Treatment:

Other: ultrasonography of the knee

Other: arthrocentesis