Determination of Immune Phenotype in Glioblastoma Patients

U

University of Ulm

Status

Completed

Conditions

Glioblastoma Multiforme

Treatments

Procedure: Surgery

Study type

Observational

Funder types

Other

Identifiers

NCT02751138
University Hospital Ulm

Details and patient eligibility

About

Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. Despite intensive research efforts and a multimodal management that actually consists of surgery, radiotherapy and chemotherapy with temozolomide, the prognosis is dismal. The aim of the current observational study is to determine immune phenotypes in individual patients with GBM at the time of diagnosis and to correlate tumor size, location (imaging), tumor properties (isocitrate dehydrogenase - 1 (IDH-1), o6-methylguanine-DNA-methyltransferase (MGMT), epidermal growth factor receptor (EGFR) mutation status, etc.) with clinical data, such as progression free and overall survival, Karnofsky index (progression free survival (PFS),overall survival (OS), Karnofsky score( KFS)), with blood immune phenotypes, biomarkers, and immune histochemical results of tumor infiltrating lymphocytes, macrophages, myeloid derived suppressor cells (MDSC), etc.. The different immunological phenotypes could predict a positive response to specific immunological therapeutic strategies and select the individual therapeutic plan for an individual GBM patient.

Enrollment

100 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

adult glioblastoma multiforme

Exclusion criteria

pregnancy, unable to give consent

Trial design

100 participants in 2 patient groups

Isocitrate dehydrogenase - 1 mutated
Description:
Immunophenotype of Glioblastoma and correlation with outcome
Treatment:
Procedure: Surgery
Isocitrate dehydrogenase - 1 wild type
Description:
Immunophenotype of Glioblastoma and correlation with outcome
Treatment:
Procedure: Surgery

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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