Determination of New Biomarkers of Septic Arthritis by Surface-Enhanced Laser Desorption/Ionization Time-Of-Flight (SELDI-TOF) (NOUBASST)

Grenoble Alpes University Hospital Center (CHU)

Status: Completed

Conditions: Acute Arthritis

Study type: Observational

Funder types: Other

Identifiers

NCT01010165

2009-A00810-57 (Registry Identifier)

0916

Details and patient eligibility

About

Septic arthritis is a frequent, potentially disabling and/or life-threatening disease. To diagnose a septic arthritis is a complex procedure, first because of numerous differential diagnoses (such as crystal arthritis), second because of poor sensitivity of initial gram staining (for example after untimely antibiotic therapy).

This protocol will use SELDI-TOF as a tool to analyse joint fluid of patients with various acute, polymorphonuclear-rich arthritis, as to determine specific and sensitive new biomarkers of a septic origin.

Such biomarkers will allow rapid diagnosis of septic arthritis in the first hours of admission.

Enrollment: 89 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• acute arthritis (onset not more than 7 days ago)
• joint fluid leukocyte count : more than 2000/mm3, more than 50% polymorphonuclear

Exclusion criteria

• none (apart from unability to accept inclusion)

Trial design

89 participants in 3 patient groups

septic arthritis

crystal arthritis

rheumatismal disease