Determination of the ED50 and ED95 of Prophylactic Norepinephrine Infusion for Preventing Post-induction Hypotension in Elderly Patients Undergoing Major Abdominal Surgery

Zhejiang University

Status: Enrolling

Conditions: Post-induction Hypotension; Norepinephrine

Treatments: Drug: norepinephrine bitartrate

Study type: Interventional

Funder types: Other

Identifiers

NCT05637164

2022-0950

Details and patient eligibility

About

The goal of this clinical trial is to determine the ED50 and ED95 of prophylactic norepinephrine infusion for preventing post-induction hypotension in elderly patients undergoing major abdominal surgery using up-and-down sequential method . The main question it aims to answer is:

What is the effective concentration of prophylactic norepinephrine infusion for preventing post-induction hypotension in elderly patients.

Participants will receive different concentrations of norepinephrine infusion at the beginning of anesthesia induction until 15 minutes after intubation.

Enrollment: 40 estimated patients

Sex: All

Ages: 65 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• aged 65 to 80 years
• Undergoing major abdominal surgery
• American Society of Anesthesiologists (ASA) physical status of I/II/III

Exclusion criteria

• Patient refusal
• Severe untreated or uncontrolled hypertension despite medications
• Bradycardia (heart rate < 50 beat per minute)
• Cardiac morbidities, heart block greater than the first degree
• Severe hepatic and renal dysfunction
• hyperthyroidism
• vascular diseases
• BMI>30
• Monoamine oxidase inhibitors were used 2 weeks before surgery

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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40 participants in 1 patient group

Norepinephrine

Experimental group

Treatment:

Drug: norepinephrine bitartrate