Determination of the Glycemic Index and the Insulinemic Index of a Sweetener Syrup

Routin SA

Status: Completed

Conditions: Healthy Volunteers

Treatments: Other: Classical sugar syrup; Other: Experimental sweetener syrup; Other: Classical sweetener syrup

Study type: Interventional

Funder types: Industry

Identifiers

NCT00717912

SIRODEX 9708

Details and patient eligibility

About

The purpose of the study is to determine the glycemic index and the insulinemic index of a sweetener syrup

Full description

Glycemic index is a measure of how carbohydrate-containing foods affect blood glucose levels. All foods that contain carbohydrates, such as starchy vegetables (potatoes, corn), desserts, fruits, bread, pasta, and rice, can be tested for how they affect blood sugar levels after being eaten. Glycemic index is assessed by having one or more people eat a specific amount of a single food (usually 50 grams of digestible carbohydrate) and then measuring the change in blood sugar levels compared with the levels achieved after they have eaten a control food containing the same amount of digestible carbohydrate, such as white bread or glucose. The average change in blood sugar levels over a set period of time relative to the levels after consumption of the control food, usually white bread or glucose, is the food's glycemic index.

Insulinemic index is measure with the same methodology.

Enrollment: 6 patients

Sex: Male

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age 18-50 years
• male
• healthy volunteers
• BMI above 25 kg/m²

Exclusion criteria

• no medical history of hypercholesterolemia, high pressure blood, diabetes, sugar intolerance
• food allergy
• kidney deficiency
• liver troubles
• gastro-intestinal troubles
• drugs which impair sugar and lipid metabolism

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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6 participants in 6 patient groups

Arm 1

Experimental group

Description:

Classical sugar syrup / Classical sweetener syrup / Classical sugar syrup / Experimental sweetener syrup / Experimental sweetener syrup / Experimental sweetener syrup / Classical sugar syrup

Treatment:

Other: Experimental sweetener syrup

Other: Classical sweetener syrup

Other: Classical sugar syrup

Arm 2

Experimental group

Description:

Experimental sweetener syrup / Experimental sweetener syrup / Classical sugar syrup / Classical sugar syrup / Classical sweetener syrup / Classical sugar syrup / Experimental sweetener syrup

Treatment:

Other: Experimental sweetener syrup

Other: Classical sweetener syrup

Other: Classical sugar syrup

Arm 3

Experimental group

Description:

Experimental sweetener syrup / Classical sugar syrup / Experimental sweetener syrup / Classical sweetener syrup / Classical sugar syrup / Classical sugar syrup / Experimental sweetener syrup

Treatment:

Other: Experimental sweetener syrup

Other: Classical sweetener syrup

Other: Classical sugar syrup

Arm 4

Experimental group

Description:

Experimental sweetener syrup / Experimental sweetener syrup / Experimental sweetener syrup / Classical sugar syrup / Classical sugar syrup / Classical sugar syrup / Classical sweetener syrup

Treatment:

Other: Experimental sweetener syrup

Other: Classical sweetener syrup

Other: Classical sugar syrup

Arm 5

Experimental group

Description:

Classical sugar syrup / Experimental sweetener syrup / Classical sweetener syrup / Experimental sweetener syrup / Experimental sweetener syrup / Classical sugar syrup / Classical sugar syrup

Treatment:

Other: Experimental sweetener syrup

Other: Classical sweetener syrup

Other: Classical sugar syrup

Arm 6

Experimental group

Description:

Experimental sweetener syrup / Experimental sweetener syrup / Experimental sweetener syrup / Classical sugar syrup / Classical sweetener syrup / Classical sugar syrup / Classical sugar syrup

Treatment:

Other: Experimental sweetener syrup

Other: Classical sweetener syrup

Other: Classical sugar syrup