Determination of the in Vitro Effects of Cationic Airway Lining Modulators (CALM) on Chronic Obstructive Pulmonary Disease (COPD) Sputum

Pulmatrix

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease

Study type: Observational

Funder types: Industry; Other U.S. Federal agency; Other

Identifiers

NCT01096173

PUL_VABUF_01

Details and patient eligibility

About

This study is intended to be an evaluation of the properties of human sputum collected from patients with COPD. It is hypothesized that cationic airway lining modulators will have beneficial effects on the rheological properties of sputum derived from patients with COPD. Approximately 10 patients with COPD will collect sputum at home for 5 days. Samples will be collected and tested in laboratory tests.

Enrollment: 10 estimated patients

Sex: All

Ages: 35 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Clinical and spirometric diagnosis of COPD
2. Smoking history of at least 10 pack yrs
3. Sputum production of greater than 2 tablespoons per day by patient report.

Exclusion criteria

1. a primary diagnosis of asthma or bronchiectasis
2. a COPD exacerbation within 4 weeks
3. Inability to comply with study procedures.