Determination of the Independent Effects of Beetroot Juice Components, Dietary Nitrate and Antioxidants, on Exercise Tolerance and Health Benefits in Individuals With Obesity (BEETIT)

The University of Alabama at Birmingham

Status: Completed

Conditions: Obesity; Metabolic Disease; Exercise

Treatments: Dietary Supplement: Beetroot Juice; Dietary Supplement: Beetroot Juice no Nitrate; Dietary Supplement: Sodium Nitrate

Study type: Interventional

Funder types: Other

Identifiers

NCT03545009

300001210

Details and patient eligibility

About

The purpose of this study is to assess the effects of acute beetroot juice supplementation on exercise performance and cardiometabolic health in obese individuals with secondary cardiometabolic complications. Additionally, we will determine if the ergogenic health benefits of beetroot juice is due to the nitric oxide compound within the product, the antioxidant compound within the product, or a combination of the two compounds.

Enrollment: 16 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI ≥ 30 kg/m2
• Able to perform exercise testing on a cycle ergometer

Exclusion criteria

• Currently taking medications know to affect cardiovascular or respiratory function
• Currently supplementing with an antioxidant compound
• Current smoker
• Currently taking antibiotics
• Not willing to abstain from mouthwash use
• Currently participating in regular physical activity

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

16 participants in 4 patient groups

Beetroot Juice

Experimental group

Treatment:

Dietary Supplement: Beetroot Juice

Beetroot Juice no Nitrate

Active Comparator group

Treatment:

Dietary Supplement: Beetroot Juice no Nitrate

Sodium Nitrate

Active Comparator group

Treatment:

Dietary Supplement: Sodium Nitrate

Control

No Intervention group