Determine the Effects of Prone Positioning and NO in COVID-19 ARDS by EIT

Fudan University

Status: Enrolling

Conditions: COVID-19; Respiratory Distress Syndrome, Adult

Treatments: Drug: NO inhalation; Behavioral: prone postion

Study type: Observational

Funder types: Other

Identifiers

NCT05715762

eit20221221

Details and patient eligibility

About

We aims to investigate the effects of prone positioning and nitric oxide inhalation in adult patients who is diagnosed with COVID-19 associated acute respiratory distress syndrome by electrical impedance tomography.

Full description

The investigators aim to investigate the effects of prone positioning and nitric oxide inhalation in adult patients who is diagnosed with COVID-19 associated acute respiratory distress syndrome by electrical impedance tomography (EIT).

The EIT assessment is performed in patients ventilated in supine position, supine position with NO inhalation for 1 hour, prone position for 1 hour, prone position for 2 hours with NO inhalation for 1 hour, prone position for 3 hours, prone position for 16 hours, re-supine position for 3 hours. Arterial blood gas (ABG) analysis results, ventilator parameters and hemodynamic parameters are also recorded at each time point.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients who have COVID-19-associated acute respiratory distress syndrome

Exclusion criteria

• patients who refuse to participate in the study; unable to use EIT, such as open-chest surgery with chest tube placement; have contraindication for prone positioning, including pregnant, post-abdomen surgery within a week; hypercapnic respiratory failure.

Trial design

20 participants in 7 patient groups

Ventilation in supine position

Description:

Patients are ventilated in supine position.

Ventilation in supine position and NO inhalation

Description:

Patients are ventilated in supine position with NO inhalation for 1 hour.

Treatment:

Drug: NO inhalation

Ventilation in prone position for 1 hour

Description:

Patients are ventilated in prone position for 1 hour.

Treatment:

Behavioral: prone postion

Ventilation in prone position for 2 hours plus NO inhalation for 1 hour

Description:

Patients are ventilated in prone position for 1 hour followed by ventilation in prone position with NO inhalation for 1 hour.

Treatment:

Drug: NO inhalation

Behavioral: prone postion

Ventilation in prone position for 3 hours

Description:

Patients are ventilated in prone position for 1 hour followed by ventilation in prone position with NO inhalation for 1 hour. Then they are ventilated in prone position alone for 1 hour.

Treatment:

Behavioral: prone postion

Ventilation in prone position for 16 hours

Description:

Patients are ventilated in prone position for 1 hour followed by ventilation in prone position with NO inhalation for 1 hour. Then they are ventilated in prone position alone for 14 hours.

Treatment:

Behavioral: prone postion

Ventilation in re-supine position for 3 hours

Description:

Patients are ventilated in supine position for 3 hours followed by ventilation in prone position for 16 hours.